Sodium-glucose co-transporter-2 inhibitors in Type 2 diabetes treatment

İrfan Karahan; Çağar Alp; Aşkın Güngüneş

doi:10.21601/ortadogutipdergisi.333690

ORTADOĞU TIP DERGİSİ - ORTADOGU MEDICAL JOURNAL

Sodium-glucose co-transporter-2 inhibitors in Type 2 diabetes treatment

Tip 2 diyabet tedavisinde sodyum-glukoz ko-transporter 2 inhibitörleri

İrfan Karahan ¹, Çağar Alp ², Aşkın Güngüneş ³ ^*

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Ortadogu Tıp Derg, Volume 10, Issue 3, pp. 381-385

https://doi.org/10.21601/ortadogutipdergisi.333690

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Abstract

Sodium-glucose co-transporter 2 (SGLT-2) inhibitors are new agents which are used in diabetes treatment. Mechanism of action is inhibiting of glucose reabsorbation and increasing of urinary glucose excretion from renal proximal tubules. These agents could improve blood pressure and weight gain disorders. Many studies showed some of these agents’ benefits on cardiovascular system. Main adverse effects are infections. Drug management and adverse effects were reviewed in this text.

Keywords: SGLT-2 inhibitors, type 2 diabetes

Öz

Sodyum-glukoz ko-transporter 2 (SGLT-2) inhibitörleri, diyabet tedavisinde yeni kullanmaya başlanılan ajanlardır. Temel etki mekanizması proksimal renal tübülden glukoz reabsorbsiyonunu engelleyerek üriner glukoz ekskresyonunu arttırmaktır. Kan basıncı ve vücut ağırlığı üzerine olumlu etkileri gösterilmiştir. Bunun dışında bazı çalışmalarda kardiyovasküler faydaları da olabileceği gösterilmiştir. Başlıca yan etkileri enfeksiyonlar olup diğer yan etkiler ve ilaç yönetimi bu yazıda tartışılmıştır.

Keywords: SGLT-2 inhibitörleri, tip 2 diyabet

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Citation

Karahan İ, Alp Ç, Güngüneş A. Sodium-glucose co-transporter-2 inhibitors in Type 2 diabetes treatment. Ortadogu Tıp Derg. 2018;10(3):381-5. https://doi.org/10.21601/ortadogutipdergisi.333690

Karahan, İ., Alp, Ç., & Güngüneş, A. (2018). Sodium-glucose co-transporter-2 inhibitors in Type 2 diabetes treatment. Ortadoğu Tıp Dergisi, 10(3), 381-385. https://doi.org/10.21601/ortadogutipdergisi.333690

Karahan, İ., Alp, Ç., and Güngüneş, A. (2018). Sodium-glucose co-transporter-2 inhibitors in Type 2 diabetes treatment. Ortadoğu Tıp Dergisi, 10(3), pp. 381-385. https://doi.org/10.21601/ortadogutipdergisi.333690

Karahan İ, Alp Ç, Güngüneş A. Sodium-glucose co-transporter-2 inhibitors in Type 2 diabetes treatment. Ortadogu Tıp Derg. 2018;10(3), 381-385. https://doi.org/10.21601/ortadogutipdergisi.333690

Karahan, İrfan, Çağar Alp, and Aşkın Güngüneş. "Sodium-glucose co-transporter-2 inhibitors in Type 2 diabetes treatment". Ortadoğu Tıp Dergisi 2018 10 no. 3 (2018): 381-385. https://doi.org/10.21601/ortadogutipdergisi.333690

Karahan, İrfan et al. "Sodium-glucose co-transporter-2 inhibitors in Type 2 diabetes treatment". Ortadoğu Tıp Dergisi, vol. 10, no. 3, 2018, pp. 381-385. https://doi.org/10.21601/ortadogutipdergisi.333690