Evaluation of gamma glutamyl transferase enzyme level in intensive care patients with sepsis related kidney function disturbance

Hamit Yıldız

doi:10.21601/ortadogutipdergisi.621138

ORTADOĞU TIP DERGİSİ - ORTADOGU MEDICAL JOURNAL

Evaluation of gamma glutamyl transferase enzyme level in intensive care patients with sepsis related kidney function disturbance

Sepsis ile ilişkili böbrek fonksiyon bozukluğu olan yoğun bakım hastalarında serum gama glutamil transferaz enzim düzeyinin değerlendirilmesi

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Ortadogu Tıp Derg, Volume 12, Issue 1, pp. 24-28

https://doi.org/10.21601/ortadogutipdergisi.621138

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Abstract

Objective: The aim of this study is to determine the relationship between serum gamma glutamyl transferase enzyme level and early diagnosis of acute renal injury due to sepsis in intensive care units.
Material and Methods: A total of 251 subjects were included in this retrospective study. 134 patients with sepsis-induced acute kidney injury were included in group 1 and 117 healthy volunteers in group 2.
Results: Serum gamma glutamyl transferase enzyme levels was found higher in patients with sepsis-induced acute renal injury than healthy volunteers. There was no significant difference between the groups according to Acute Kidney Injury Network (AKIN) staging (p=0.09).
Conclusion: High serum gamma glutamyl transferase enzyme levels may be used in early detection of acute renal injury in patients with sepsis.

Keywords: sepsis, gamma glutamyl transferase, kidney function disturbance

Öz

Amaç: Yoğun bakımlarda sık görülen sepsise bağlı akut böbrek hasarının erken tanısında serum gama glutamil transferaz enzim düzeyinin ilişkisi tespit etmektir.
Gereç ve Yöntemler: Bu retrospektif çalışmaya toplam 251 adet denek alındı. Sepsise bağlı akut böbrek hasarlı 134 hasta grup 1’e ve 117 adet sağlıklı gönüllü grup 2’ye alındı.
Bulgular: Serum gama glutamil transferaz enzim düzeyi sepsise bağlı akut böbrek hasarı gelişen hastalarda sağlıklı gönüllülere göre daha yüksek bulundu. Acute Kidney Injury Network (AKIN) evrelemesine göre gruplar arasında anlamlı fark bulunmadı (p=0,09).
Sonuç: Sepsisli hastalarda serum gama glutamil transferaz enzim yüksekliği akut böbrek hasarının erken saptanmasında kullanılabilir.

Keywords: sepsis, gama glutamil transferaz, böbrek fonksiyon bozukluğu

References

Vincent JL, Opal SM, Masrhall JC, Tracey KJ. Sepsis definitions. Time for change. Lancet 2013;381(9868):774-5.
Linde-Zwirble WT, Angus DC. Severe sepsis epidemiology: Sampling, selection, and society. Crit Care 2004;8:222-6.
Singer M, Deutschman CS, Seymour CW. The third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA 2016;315:801-10.
Chertow Gm, Levy, EM, Hammermeister KE, Grover F, Daley J. Independent association between renal failure and mortality following cardiac surgery. Am J Med 1998;104:343-8.
Hoste EA, Kellum JA. Acute renal failure in the critically ill: Impact on morbidity and mortality. Contrib Nephrol 2004;144:1-11.
Singbaartl K, Kellum JA. AKI in the ICU: Definition, epidemiology, risk stratification, and outcomes. Kidney Int 2012;81: 819-25.
Ostermann M, Chang RW. Acute kidney injury in the intensive care unit according to RIFLE. Crit Care Med 2007;35:1837-43.
Uchino S, Kellum JA, Bellomo R, Doig GS, Morimatsu H, Morgera S, ve ark. Acute renal failure in critically ill patients: A multinational, multicenter study. JAMA 2005;294:813-8.
Roy AK, Mc Gorrian C, Treacy C, Kavanaugh E, Brennan A, Mahon NG, ve ark. A comparison of traditional and novel definitions (RIFLE, AKIN, and KDIGO) of acute kidney injury for the prediction of outcomes in acute decompensated heart failure. Cardiorenal Med 2013;3:26-37.
Dufour DR, Lott JA, NOlte FS, Gretcch DR, Koff RS, Seeff LB. Diagnosis and monitoring of hepatic injury. I. Performance characteristics of laboratory tests. Clin Chem. 2000 Dec;46(12):2027-49.
Targher G. Elevated serum gamma-glutamyltransferase activity is associated with increased risk of mortality, incident type 2 diabetes, cardiovasular events, chronic kidney disease ad cancer-a narrative review. Clin Chem Lab Med. 2010;48:147-57.
Bulusu S, Sharma M. What does serum gama glutamilstranfaraz tell us as a cardiometabolic risk marker? Ann Clin Biochem. 2016;53 Pt 3:312-32.
Kinner HA, Hot S, Schuller R, Roy J, Israel Y. Identification of alcohol abuse using laboratory tests and a history of trauma. Ann Inter MEd 1984;101:847-51.
Conigrave KM, Saunders JB, Reznik RB, Whitfield JB. Prediction of alcohol-related harm by laboratory test results. Clin Chem 1993;39:2266-70.
Caravaca F, Azevedo L, Bayo MA, Gonzales-Candia B, Luna E, Caravaca F. High levels of both serum gama-glutamyl transferase and alkaline phospatase are independet predictors of mortality in patients with stage 4-5 chronic kidney disease. Nefrologia. 2017 May – Jun;37(3):267-75.
Teppala S, Shankar A, Li J, Wong TY, Ducatman A. Association between serum gama-glutamyltransferase and chronic kidney disease among US adults. Kidney Blood Press Res. 2010;33(1):1-6.
Serafim R, Gomes JA, Salluh J, Povoa P. A comparison of the Quick-SOFA and Systemic inflammatory response syndrome criteria for the diagnosis of sepsis and prediction of mortality: A systemic review and meta-analysis. Chest 2018;153(3):646.
Kaukonen KM, Bailey M, Suzuki S, Pilcher D, Bellomo R. Mortality related to severe sepsis ans septic shock among critically ill patients in Australia and New Zealand, 2000-2012. JAMA. 2014;311(13):1308.
Esper AM, Martin GS. Extending international sepsis epidemiology: the impact of organ dysfunction. Crit Care. 2009;13(1):120.
Blanco J, Muriel-Bombin A, Sagredo V, Taboada F, Gandia F, Tamayo L, ve ark. Incidence, organ dysfunction and mortality in severe sepsis: a Spanish multicentre study. Crit Care. 2008;12(6):R158.
Danai Pa, Sinha S, Moss M, Haber MJ, Martin GS. Seasonal variation in the epidemiology of sepsis. Crit Care Med. 2007;35(2):410.
Uslan DZ, Crane SJ, Steckelberg JM, Cockerill FR, St Sauver JL, Wilson WR, ve ark. Age and sex-associated trends in bloodstream infection: a population-based study in Olmsted Country, Minnesota. Arch Intern med. 2007;Apr;167(8):834-9.
Pop-Vicas A, Tacconelli E, Gravenstein S, Lu B, D’Agata EM. Influx of multidrug-resistant, gram-negative bacteria in the hospital setting and the role of elderly patients with bacterial bloodstream infection. Infect Control Hosp Epidemiol. 2009 Apr;30(4):325-31.
Martin GS, Mannino DM, Eaton S, Moss M. The epidemiology of sepsis in the United States from 1979 through 2000. N Eng J Med. 2003;348(16):1546.
Gupta S, Sakhuja A, Kumar G, McGrath E, Nanchal RS, Kashani KB. Culture-negative severe sepsis: nationwide trends and outcomes. Chest.2016;150(6):1251.
Bellomo R, Ronco C, Kellum JA, Mehta RL, Palevsky P. Acute renal failure-definition, outcome measures, animal-models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) group. Crit Care 2004;8:R204.

Citation

Yıldız H. Evaluation of gamma glutamyl transferase enzyme level in intensive care patients with sepsis related kidney function disturbance. Ortadogu Tıp Derg. 2020;12(1):24-8. https://doi.org/10.21601/ortadogutipdergisi.621138

Yıldız, H. (2020). Evaluation of gamma glutamyl transferase enzyme level in intensive care patients with sepsis related kidney function disturbance. Ortadoğu Tıp Dergisi, 12(1), 24-28. https://doi.org/10.21601/ortadogutipdergisi.621138

Yıldız, H. (2020). Evaluation of gamma glutamyl transferase enzyme level in intensive care patients with sepsis related kidney function disturbance. Ortadoğu Tıp Dergisi, 12(1), pp. 24-28. https://doi.org/10.21601/ortadogutipdergisi.621138

Yıldız H. Evaluation of gamma glutamyl transferase enzyme level in intensive care patients with sepsis related kidney function disturbance. Ortadogu Tıp Derg. 2020;12(1), 24-28. https://doi.org/10.21601/ortadogutipdergisi.621138

Yıldız, Hamit. "Evaluation of gamma glutamyl transferase enzyme level in intensive care patients with sepsis related kidney function disturbance". Ortadoğu Tıp Dergisi 2020 12 no. 1 (2020): 24-28. https://doi.org/10.21601/ortadogutipdergisi.621138

Yıldız, Hamit "Evaluation of gamma glutamyl transferase enzyme level in intensive care patients with sepsis related kidney function disturbance". Ortadoğu Tıp Dergisi, vol. 12, no. 1, 2020, pp. 24-28. https://doi.org/10.21601/ortadogutipdergisi.621138